Microblog Memes

American here: I know paracetamol is acetaminophen, but how much is a packet?

Not "even paracetamol". ESPECIALLY paracetamol.

Tylenol/acetaminophen/paracetamol is both weak ass painkiller and really dangerous because the overdose line is low. Here they put it in synthetic opioid drugs, it doesn't help with pain but does make them more dangerous.

Couldn't they have given the liver to someone who was less of an idiot?

I think what's extra dangerous about Tylenol is that it doesnt feel like it's doing anything. When it works, some minor pain goes away, or maybe your fever goes down. But there's no side effects that you really feel, so I bet people get a false sense of security with it. Like, oh it isn't giving me opioid euphoria, or knocking me out. And you can just buy as much as you want, no restrictions. It must be perfectly safe.

how the fuck did they find a donor so fast???

That guys a moron. The bottles are very very clear not to take more than the recommended dosage. Its labeled all over the bottle.

PSA: stupidity is dangerous

It's bizarre to me that someone can make it to adulthood without knowing that paracetamol specifically is no fucking joke.

Is this real? Who gets a liver donor in 4 days?

You know what else is stupid? Pain management in the US. I get that you need to be careful about addiction, but the idea that people should have to suffer pain because we're having a pain medication "reefer madness" spasm is idiocy.

The guy just kept taking them until his teeth stopped hurting. Why is the alternative that he just has to put up with being in pain?

I mean this is just dumb. Like I’m sorry but this would happen with basically every medicine or drug. They aren’t made to be taken at higher doses than advised.

(Imagine you took 8 liters of beer per day for 3 days, you’d be half dead too.)

Moderation people…

He's lucky it was just his liver. People who overdose or try to commit suicide with it are not in for a good time or quick death and after it's absorbed into your body it will cause a systemic shutdown of several organs like the kidneys and pancreas. Not just the liver, and there's absolutely no way to counteract this after that first 36 hours. You will die (you aren't getting all of the organs replaced) and it will take days before you succumb. No antidote or life support or anything can be done for you.

You'll feel fine the first day but may have some vomiting. By day 3 the jaundice and stomach pain sets in as the liver is first to show signs of the organs failure and it's no longer possible to counteract the drug. By the fourth day your organs start shutting down and you'll have much more pain and vomiting. All that can be done is get your affairs in order because you'll be dead and in pain while you wait around to die and regret your suicide.

I say suicide because it's almost always intentional. It usually takes 40 325mg pills to cause this, although the liver damage can be caused with 20+ pills in an adult, generally. If you think you've possibly overdosed get to the hospital quick and tell them what you've taken so they can start you on Acytylcystine. If you "feel fine" after the first day or so and think you're all good you may be wrong and when day Tyree rolls around and your feeling bad or jaundiced your liver is already wrecked and can't be fixed.

My brother in Christ, the paracetamol box LITERALLY says to never go more than 4 grams (4000 mg) in a 24hs period on any mg pills presentation

And as far as I see, that's a general rule with everything. Even those caramels for sore throat or reflux pills, where you'd need to eat thousands in a day to overdose, say the same

Don't fuck with medicine dudes

Sounds like American healthcare to me.

You either cope, and probably cause irreparable hard to yourself, or you go to the clinic or ER and get labeled a drug seeker.

It's people like this who make other people think any amount of painkillers is bad, and seem to get a sense of superiority about them for never taking any.

He's not the first one to 'kill his liver' with paracetamol/ acetominophen (tylenol). First case I recall, the person was taking tylenol nightly with a glass of wine. Here's some links on the current understanding of Liver injury and paracetamol:

Apparently it's not always overdosing: Paracetamol-induced hepatotoxicity at recommended dosage (https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2796.2003.01097.x)

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update (https://pmc.ncbi.nlm.nih.gov/articles/PMC4913076/) "...in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases."

Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults (https://www.mdpi.com/1648-9144/57/8/752) "In the univariable analysis, significant hepatotoxicity risk factors were male gender, alcohol abuse, an ingested paracetamol dose, and a timespan from ingestion to hospital admission. The later one was the only significant risk factor in the multivariable model (adjusted odds ratio 1.08; 95% CI: 1.03–1.12)."

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (https://pubmed.ncbi.nlm.nih.gov/37436926/) "Where data were available, we estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury."

Understanding paracetamol-induced liver failure (https://link.springer.com/article/10.1007/s00134-014-3293-9)

It's why in the UK shops won't sell more than 2 packets at a time. It's statistically reduced the amount of people killing themselves with them (intentionally or by mistake).

How big is a packet?