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Smallpox is the only infectious disease to be successfully iradicated. The last case occured in 1978. However, the US (CDC) and Russia maintain samples of the virus for research purposes, despite the WHO's recommendation that all samples of the virus be destroyed.
Given the current state of things, I wouldn't consider it completely impossible for some very stable genius to accidently -- or maybe not accidentally -- release the virus back into the wild.
Im getting a hankering for bear head tonight.