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Smallpox is the only infectious disease to be successfully iradicated. The last case occured in 1978. However, the US (CDC) and Russia maintain samples of the virus for research purposes, despite the WHO's recommendation that all samples of the virus be destroyed.
Given the current state of things, I wouldn't consider it completely impossible for some very stable genius to accidently -- or maybe not accidentally -- release the virus back into the wild.
Should we bet on which excuse they will use for reintroducing smallpox?
”See? If vaccines were so effective, how come smallpox is still around?”
”It helps build the natural immune system”
”We must close the borders so no one gets in - or out!”
”Hunter Biden’s laptop!!!”
"But her emails!"