Gintama is a gag anime and is for the most part episodic so you can usually jump into any episode without missing much. There's an overarching plotline where aliens came to Japan during the age of the samurai who all fought against them. The aliens won because space is massive and there are many races of aliens and mercenaries, but ultimately Earth just became another planet to visit and trade with. The samurai resistance was fierce so the aliens banned swords except for the police. This plotline only matters for a few bigger arcs but mainly it just explains why there are samurai with modern and futuristic technology.

The main cast is a ragtag trio who will take on any request for money, the main character is lazy but loyal, and the characters in the clip are friendly reoccurring characters. The guy with the glasses is named Shinpachi and is part of the Odd Jobs trio. He's an awkward character who is too shy and awkward to find romance and is obsessed with a kpop idol.

Those Pandemonium bugs are a snack that demons enjoy eating but they can transform their face into anything. Shinpachi ends up falling in love with it because he's so desperate for love. It became a reoccurring bit where the Pandemonium shows up in multiple episodes and Shinpachi who is usually the straight-man completely loses his role as he's head over heels in love with this grotesque bug that everyone else sees as disgusting