After the most recent flu or cold I had. I would do anything for a cold vaccine. Flu shot likely kept me safe from that last bug I had. But still would like a cold vaccine to.
this post was submitted on 25 Mar 2025
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About a month ago I had the flu - the real flu - for the first time either in ages, or in my life, and I actually had gotten vaccinated in autumn, and man, I thought I was dying. For two weeks I couldn't do anything. Just looking at the stairs gave me endocarditis. I never run fevers and I was just popping painkillers to keep it under 40 degrees. That was nuts. So during and afterwards I mostly been thinking about three things: 1. I would have died for real if I didn't have some basic protection from the vaccine, 2. I want a vaccine against the common cold as well, and 3. Jesus Christ please I don't want to die from a stupid cold or flu, at least make it Covid, but that's such a lowball way to go
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I had the cold and COVID back-to-back. I felt much worse with the cold. It turned into a chest infection that took about three weeks to get over. And then right as I got over that, I caught COVID. I was just tired with COVID. Like I had a fever and some coughing, but aside from that I was just sleepy.
Joke’s on me though; That was over a year ago, and I still have long COVID. The coughing is gone, but I’m still fucking tired constantly. Doesn’t matter how much sleep I get. Ironically, it means I sleep a lot less, because if I’m going to be tired regardless, why waste the time being asleep?
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OK, so if I understand this correctly, they don't train the immune system to target these sugars, since they're used by human cells. Instead, they remove them during the vaccine administration so the immune system can train on the bare spike protein. Cool. Now how would this help when new virus copies come in with sugar-coated proteins, some time after the sugar stripping agent is gone from the system?
What they've found, from the article, and abstract (alas I didn't see any links to full text paper, which may come available after the ACS Spring 2025 meeting), is that they indeed do get an effective broad based immune response against coronaviruses. The 'sugar stripping agent' process is used in the production of the immunogen (basically a glycan stripped version of the more highly conserved spike protein that occurs in all/ many/ a lot of coronaviruses, i.e. which cause common cold, MERS, and COVID19), such that a broad based immune response is evoked when applying it, some time after the sugars (glycans) have already been stripped. Remember the spike is the consistent (conserved) part, and the glycans are the camouflage bits. Researchers have been trying to come up with something based on the spike protein for some time, and this is the sort of breakthrough that they've been working towards. Doubtless more info will be available after the research has been officially presented, March 23-27. (https://www.acs.org/meetings/acs-meetings/spring.html) So it's literally happening now. And may show up on Chi-Huey Wong's google scholar page (https://scholar.google.com/citations?user=GQLirSoAAAAJ) or at Scripps/Sinica (https://www.genomics.sinica.edu.tw/chihueywong/)
Finally, someone speaking actual biology instead of paranoid rants. Impressive grasp of glycosylation and conserved epitope exposure - you've clearly done your reading beyond headlines. The sugar-stripping approach is ingenious precisely because it targets what viruses try to hide. Current research trajectory looks promising but I'll wait for peer-reviewed publications after that ACS meeting before joining the hype train.
🐱🐱🐱🐱🐱
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Yeah I also don't understand this part. Can the antibodies targeting the bare spike protein attach to it despite the presence of the sugars? Or are there a few spike proteins in the virus which do not have the sugars, not enough to effectively develop antibodies but enough for already existing antibodies to attach to?
I may have missed it in the article, I'm not in life sciences so I don't have all the prerequisite knowledge for this
Edit: this came out sounding super negative, I'm actually super excited about this development and all I want is to understand a bit better how it works
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I wonder how this could help those with long COVID.
long covid, aka sequelae (medical term) means you had a long last complication that seperate from the virus. the inflammation couldve damaged parts of your body you are chronically suffering from. it might not help, since its not caused by the virus anymore.
its basically like having PHN, or nerve damage after shingles, the vaccine wont help you with that.
Well, I'm fucked.
Sometimes the nody heals though slowly, for me it took a first 6-9 months to get over the worst, and I'm way better today.
Many long COVID infections are causing/caused significant damage to organs (https://pmc.ncbi.nlm.nih.gov/articles/PMC11834749/). A vaccination isn't going to reverse organ damage.
I don't think it's going to help them. long covid is past the stage of virus infection. It's where the body is attacking itself.
It depends! Sometimes it's autoimmune, sometimes it's lingering virus, sometimes it's disrupted regulatory systems, etc. When it's the immune system or lingering virus, a new vaccine can often get the immune system to relearn how to correctly handle the virus
Doesn't chickenpox turn into shingles by infecting the nervous system?
Could long covid be related to that?
The virus that causes chicken pox, lies dormant in your nervous system, where your immune system can’t get it, for decades. Then much later in life the virus can reactivate, infect along those nerves, causing shingles.
This is the important part of the chicken pox vaccination the we don’t talk about nearly enough.
- If you get chicken pox, you’ll probably be ok (although not everyone is) and get over it, becoming immune. But the virus will still lurk, opening you to shingles attacks when you’re much older
- if you get the vaccination, you’ll probably not only not get chicken pox, but will also not get shingles
Supposedly something like one in three elderly will get shingles, when they can’t as easily deal with it. As current generation gets old, that illness will practically disappear
We can save shingles if we stop vaccinating now!
If you have older relatives and friends (50+), do remind them that we have shingles vaccine: Shingrix.
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Took me over half a year to get over covid.last time. I coughed so.much and so hard for so long I got a hernia.
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