this post was submitted on 05 May 2025
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Uplifting News

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[–] Guidy@lemmy.world 2 points 1 hour ago

Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

That'd be... neat.

[–] Bluetreefrog@lemmy.world 4 points 2 hours ago (1 children)
[–] ColeSloth@discuss.tchncs.de 2 points 2 hours ago

Ah yes. The mild ache pain slightly less medication.

[–] ripcord@lemmy.world 2 points 3 hours ago

This does sound like great news.

[–] surfrock66@lemmy.world 84 points 10 hours ago (2 children)

There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

[–] surewhynotlem@lemmy.world 25 points 10 hours ago (1 children)

For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

[–] FistingEnthusiast@lemmynsfw.com 4 points 7 hours ago

I'd take it for sure

[–] homesweethomeMrL@lemmy.world 5 points 6 hours ago

What a weird site.

PR releases b/w standard blog fare and meta numbers discussion?

[–] altphoto@lemmy.today -2 points 3 hours ago

Its great! And if you pop the miniature eyes that grow behind your ear in the first month, you don't have to get them surgically removed! A lot of people might think "hmm extra eyes! Heck yeah!" But what they don't get is how weird everything looks from behind. And the blinking! Nobody wants to be behind you and watch you blink. But you just pop them first sight and you'll be happy as a clown!... Clam! Sorry!

[–] Trimatrix@lemmy.world 8 points 11 hours ago (2 children)

I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

[–] Mbourgon@lemmy.world 19 points 10 hours ago (1 children)

“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”

https://www.scientificamerican.com/article/what-is-journavx-the-new-opioid-free-painkiller-from-vertex/

[–] TheTechnician27@lemmy.world 10 points 9 hours ago* (last edited 9 hours ago) (1 children)

Alternative: send Vertex Pharmaceuticals' board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

[–] huppakee@lemm.ee 2 points 7 hours ago (2 children)

Yes that will get people to do research and make new meds available. /s

[–] TheTechnician27@lemmy.world 14 points 6 hours ago* (last edited 6 hours ago) (2 children)

Should I have added "nationalize it and make future research funded and owned by the public"? (A lot of public funding already goes to medical research, but the profits get privatized.)

Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn't the only way to do medical research.

[–] Natanox@discuss.tchncs.de 1 points 6 hours ago

That's the way.

[–] huppakee@lemm.ee 0 points 5 hours ago

The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I'm not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

[–] Doomsider@lemmy.world 0 points 3 hours ago

Found the corporate bootlicker.

[–] Mouselemming@sh.itjust.works 6 points 10 hours ago (1 children)

I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

[–] Trimatrix@lemmy.world 1 points 6 hours ago

Yeah…. My bad

[–] ModestCrab@lemmy.wtf 5 points 11 hours ago (4 children)

significantly more favorable side effect profile

So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

[–] 11111one11111@lemmy.world 12 points 10 hours ago

It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

[–] don@lemm.ee 3 points 10 hours ago (1 children)

There’s this at the bottom of the article. It may have what you’re looking for.

[–] ColeSloth@discuss.tchncs.de 1 points 2 hours ago

I dont see it.

[–] DavidGarcia@feddit.nl 2 points 11 hours ago (2 children)

I'll only make your dick fall off (and grow one first if you don't have one)

[–] Natanox@discuss.tchncs.de 3 points 6 hours ago

So it even doubles as non-invasive sex reassigment surgery precursor drug? Damn, this medicine is multifunctional as hell!

[–] Laser@feddit.org 4 points 10 hours ago

It's gonna be a huge success with Lemmy users