this post was submitted on 05 May 2025
277 points (98.6% liked)

Uplifting News

14863 readers
1532 users here now

Welcome to /c/UpliftingNews, a dedicated space where optimism and positivity converge to bring you the most heartening and inspiring stories from around the world. We strive to curate and share content that lights up your day, invigorates your spirit, and inspires you to spread positivity in your own way. This is a sanctuary for those seeking a break from the incessant negativity often found in today's news cycle. From acts of everyday kindness to large-scale philanthropic efforts, from individual achievements to community triumphs, we bring you news that gives hope, fosters empathy, and strengthens the belief in humanity's capacity for good.

Here in /c/UpliftingNews, we uphold the values of respect, empathy, and inclusivity, fostering a supportive and vibrant community. We encourage you to share your positive news, comment, engage in uplifting conversations, and find solace in the goodness that exists around us. We are more than a news-sharing platform; we are a community built on the power of positivity and the collective desire for a more hopeful world. Remember, your small acts of kindness can be someone else's big ray of hope. Be part of the positivity revolution; share, uplift, inspire!

founded 2 years ago
MODERATORS
wolfeh@lemmy.world
Flummoxed@lemmy.today
sga@lemmings.world
sga013@lemmy.world
plantmoretrees@lemm.ee
277
Revolution in pain management: first non-opioid drug arrives (hive.blog)
submitted 1 day ago by Merlu@lemmy.ml to c/upliftingnews@lemmy.world
42 comments fedilink hide all child comments
all 44 comments
sorted by: hot top controversial new old
[–] captainlezbian@lemmy.world 2 points 2 hours ago

Even if it had similar addiction profiles to opioids I'd be all for it. Opioid allergies are very common and those of us who have them also deserve to not be in agony after surgeries or physical trauma.

In fact, I worry that if its nonaddictive it may be pushed onto people who are allergic or nonresponsive to it similar to how nonstimulant adhd meds are. That doesn't mean I'm not all for nonaddictive painkillers, I'm 100% in favor and if we had a few options that can cover our bases I'd be in favor of shelving the poppy juice into a last resort role, but I hope people don't lose their sense of nuance in it.

[–] RizzRustbolt@lemmy.world 1 points 2 hours ago

Is this BBB soluble like gabapentin?

[–] Guidy@lemmy.world 14 points 15 hours ago

Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

That'd be... neat.

[–] surfrock66@lemmy.world 102 points 1 day ago (2 children)

There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

[–] surewhynotlem@lemmy.world 32 points 1 day ago (1 children)

For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

[–] FistingEnthusiast@lemmynsfw.com 6 points 21 hours ago (1 children)

I'd take it for sure

[–] blarghly@lemmy.world 3 points 3 hours ago

A drug that gives you the feeling of bbqing with friends and family in the city park. Lit

[–] Bluetreefrog@lemmy.world 5 points 16 hours ago (1 children)

Aspirin has entered chat.

[–] ColeSloth@discuss.tchncs.de 4 points 16 hours ago

Ah yes. The mild ache pain slightly less medication.

[–] homesweethomeMrL@lemmy.world 7 points 21 hours ago

What a weird site.

PR releases b/w standard blog fare and meta numbers discussion?

[–] ripcord@lemmy.world 3 points 17 hours ago

This does sound like great news.

[–] Trimatrix@lemmy.world 9 points 1 day ago (2 children)

I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

[–] Mbourgon@lemmy.world 23 points 1 day ago (1 children)

“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”

https://www.scientificamerican.com/article/what-is-journavx-the-new-opioid-free-painkiller-from-vertex/

[–] TheTechnician27@lemmy.world 13 points 23 hours ago* (last edited 23 hours ago) (1 children)

Alternative: send Vertex Pharmaceuticals' board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

[–] huppakee@lemm.ee 3 points 21 hours ago (2 children)

Yes that will get people to do research and make new meds available. /s

[–] TheTechnician27@lemmy.world 19 points 20 hours ago* (last edited 20 hours ago) (2 children)

Should I have added "nationalize it and make future research funded and owned by the public"? (A lot of public funding already goes to medical research, but the profits get privatized.)

Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn't the only way to do medical research.

[–] Natanox@discuss.tchncs.de 1 points 20 hours ago

That's the way.

[–] huppakee@lemm.ee -1 points 19 hours ago

The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I'm not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

[–] Doomsider@lemmy.world 4 points 18 hours ago

Found the corporate bootlicker.

[–] Mouselemming@sh.itjust.works 7 points 1 day ago (1 children)

I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

[–] Trimatrix@lemmy.world 1 points 20 hours ago

Yeah…. My bad

[–] ModestCrab@lemmy.wtf 5 points 1 day ago (4 children)

significantly more favorable side effect profile

So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

[–] 11111one11111@lemmy.world 15 points 1 day ago

It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

[–] don@lemm.ee 3 points 1 day ago (1 children)

There’s this at the bottom of the article. It may have what you’re looking for.

[–] ColeSloth@discuss.tchncs.de 1 points 16 hours ago

I dont see it.

[–] DavidGarcia@feddit.nl 2 points 1 day ago (2 children)

I'll only make your dick fall off (and grow one first if you don't have one)

[–] Natanox@discuss.tchncs.de 4 points 20 hours ago (1 children)

So it even doubles as non-invasive sex reassigment surgery precursor drug? Damn, this medicine is multifunctional as hell!

[–] captainlezbian@lemmy.world 1 points 2 hours ago

The evolved form of spironolactone

[–] Laser@feddit.org 5 points 1 day ago

It's gonna be a huge success with Lemmy users